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Recherche de candidat en thèse / PhD student - Organic / inorganic particles for the treatment of complex wounds with high risk of infection

PhD position in Institute of Biomolecules Max Mousseron (IBMM, Montpellier, France) and CIRIMAT (Toulouse, FRANCE)
Chemistry /Biology interface.
Starting date : October-November 2019

Contacts :
IBMM Montpellier : gilles.subra umontpellier.fr (www.ibmmpeptide.com)
CIRIMAT Toulouse : christophe.drouet cirimat.fr (www.christophedrouet.com)

Organic / inorganic particles for the treatment of complex wounds with high risk of infection

Keywords : mineral nanoparticles, peptides, wound-healing, antibacterial, hybrid materials
Starting date : October 2019-october 2022
Funding : Institut Carnot Chimie Balard Cirimat

Summary :
This PhD project focuses on the design and the study of hybrid mineral/organic particles which will be stabilized by biomolecules and in particular bioactive peptides. The antibacterial and wound healing effect of the particles will be evaluated.
Challenges :
Open wounds are common in all health services, from emergencies to dermatology, maxillofacial, orthopedic and plastic surgery. In the case of deep wounds, infection is a major threat to the health of the patient, especially for the most fragile subjects such as the elderly, diabetic patients, immuno-depressed or burnt victims. Innovative solutions need to be developed for the most complex wounds where coordinated (antibacterial and pro-healing) effects are required to achieve optimal healing. In addition, current solutions are generally based on general antibiotic therapy, but microbial resistance is becoming a major public health problem, and alternative solutions are needed.

Scientific approach :
In this context, the project will aim to design an alternative solution to conventional dressings and systemic antibiotic treatments through the development of sub-micron peptide-associated mineral particles for the controlled release of active agents. The formulation of these hybrid particles in the form of a medical device of the dressing and / or ointment type will also be explored.

Candidate profile : (molecular) chemistry background. A preliminary experience on peptides synthesis and characterization will be a plus. The PhD student will spend part of the time in Montpellier and part in Toulouse, autonomy , self-organization and mobility is required.

How to apply ?
A detailed CV (with names of two references) and a cover letter should be emailed to the supervisors